Search This Blog

Risk factors for Breast Cancer.


BRCA1/BRCA2 mutation- They act as tumor suppressor genes, since cancer arises when both alleles are inactive or defective-one caused by a germ-line mutation and the second by a subsequent somatic mutation

HER2/NEU proto-oncogene, which has been found to be amplified in up to 30% of invasive breast cancers. This gene is a member of the epidermal growth factor receptor family, and its overexpression is associated with a poor prognosis

Women are more likely to carry a breast cancer susceptibility gene if
1.they develop breast cancer before menopause,
2.have bilateral cancer,
3.have other associated cancers (e.g., ovarian cancer),
4.have a significant family history (i.e., multiple relatives affected before menopause), or
belong to certain ethnic groups.

Li-Fraumeni syndrome (caused by germ-line mutations in p53

Cowden disease (caused by germ-line mutations in PTEN
carriers of the ataxia-telangiectasia gene
amplification of RAS and MYC genes
Mutations of the well-known tumor suppressor genes RB and p53 may also be present.

Risk factors contd….

Prolonged exposure to exogenous estrogens

postmenopausally, known as hormone replacement therapy
Oral contraceptives: balanced low doses of combined estrogens and progestins seem to be safe
long duration of reproductive life,
nulliparity, and
late age at birth of first child

20% to 30% of women irradiated for Hodgkin lymphoma in their teens and 20s develop breast cancer, but the risk for women treated later in life is not elevated

obesity, alcohol consumption, and a diet high in fat.

7 comments:

  1. I think this is an informative post and it is very useful and knowledgeable. therefore, I would like to thank you for the efforts you have made in writing this article. Breast cancer

    ReplyDelete
  2. Really nice and interesting post. I was looking for this kind of information and enjoyed reading this one. Keep posting. Thanks for sharing. cronache pescara

    ReplyDelete
  3. For ladies who want completion in the upper shafts of their breasts, the round is a decent decision.
    Motiva breast implants

    ReplyDelete
  4. That is a direct result of the bodies stunning Resistant Framework that ceaselessly watches our body and takes out unfamiliar intruders, including the recently shaping cancer cells. how much cbd is in hemp oil

    ReplyDelete
  5. Just as of late it has been accounted for that specialists were finding that enemy of parasitic medications were restoring cancer coincidentally. how many mg cbd oil for pain

    ReplyDelete
  6. Infiltrating Lobular: Representing 15 percent of breast cancers, these lesions generally appear in the upper outer quadrant of the breast as a subtle thickening and are difficult to diagnose by mammography. Breast Cancer

    ReplyDelete
  7. I really loved reading your blog. It was very well authored and easy to understand. Unlike other blogs I have read which are really not that good.Thanks a lot! motiva breast augmentation

    ReplyDelete