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Teratogenic drugs and their effects

Teratogenic drugs and their effects

Alcohol in pregnancy -- Fetal Alcohol Syndrome (FAH) - Midfacial hypoplasia and Long philtrum

Using DES in pregnancy - New born with T shaped Uterus

Dilantin/Phenytoin -- Craniofacial dysmorphism (5-10%) and also nail hypoplasia

Isotretinoin (Accutane) - Microtia -small ear - severe birth defects also heart problem

Lithium - Ebstein anomaly - large Right arium

Tetracyclin - Deciduous teeth discoloration (after 4 month)

Thalidomide - Phocomelia (Limb reduction defects exposure from Day 42-48)

Valproic Acid (Depakote) - Neural Tube Defects like Spina bifida , Congenital Heart disease

Coumadin - Chondrodysplasia punctata also optic atrophy


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