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Prenatal Diagnostic Testing Schedule


Prenatal visits  

  • Weeks 0-28: Every 4 weeks. 
  • Weeks 29-35: Every 2 weeks. 
  • Weeks 36-birth: Every week. 

Initial visit :

Heme:  CBC, Rh factor ,  type  and  screen.

Infectious disease:

UA and culture,  rubella  antibody titer , HBsAg,
RPR/VDRL, cervical gonorrhea and chlamydia, PPD, HIV,  Pap
smear (to check for dysplasia). Consider HCV and varicella based
on history.

If indicated: HbA, sickle cell screening.
Discuss genetic screening:  Tay-Sachs disease, cystic fibrosis.

9- 14  weeks :

Offer PAPP-A +  nuchal transparency + free  B-hCG +/- chorionic
villus sampling  (CVS)

15-22 weeks :

Offer maternal  serum a-fetoprotein  (MSAFP)  or quad screen  (AFP,
estriol,  P-hCG, and inhibin A)  +/- amniocentesis.

18-20 weeks :

Ultrasound for full  anatomic screen.

24-28 weeks : 

One-hour glucose  challenge test for gestational diabetes screen.

28-30 weeks :

RhoGAM for  Rh-8 women (after antibody screen).

35-40 weeks :

Group  B  strep  culture  (GBS);  repeat CBC.

34-40 weeks :

Cervical chlamydia  and  gonorrhea cultu res,  HIV,  RPR  in high-risk patients.

Common Antibodies and Their Disease Associations

Common Antibodies and Their Disease Associations


  1. ANA  SLE 
  2. Anti-CCP  RA 
  3. Anti  centromere  CREST  syndrome 
  4. Anti-dsDNA  SLE 
  5. Anti  histone  Drug-induced  SLE 
  6. Anti-Jo- 1  Polymyositis/dermatomyositis 
  7. Anti  mitochondrial  Primary biliary cirrhosis 
  8. Antinuclear  Scleroderma 
  9. Anti-Scl-70  Scleroderma 
  10. Anti-Sm  SLE 
  11. Anti-smooth muscle  Autoimmune hepatitis 
  12. Antitopoisomerase I  Scleroderma 
  13. Anti-TSHR  Graves'  disease 
  14. c-ANCA  Vasculitis, especially Wegener's 
  15. p-ANCA  Vasculitis,  microscopic polyangiitis 
  16. Rheumatoid factor  RA 
  17. Ul  RNP antibody  Mixed connective tissue disease

Common AIDS-defining illnesses and Opportunistic infections

Common AIDS-defining illnesses:

  • Esophageal candidiasis 
  • CMV retinitis 
  • Kaposi's sarcoma 
  • CNS  lymphoma, toxoplasmosis, PML 
  • P jiroveci pneumonia  or  recurrent bacterial  pneumonia 
  • HIV encephalopathy 
  • Disseminated  mycobacterial or fungal infection 
  • Invasive cervical cancer