List of Granulomatous diseases

• Bartonella henselae(cat scratch disease)
• Berylliosis
• Churg-Strauss syndrome
• Crohn disease
• Francisella tularensis
• Fungal infections (e.g., histoplasmosis, 
• blastomycosis)
• Granulomatosis with polyangiitis (Wegener)
• Listeria monocytogenes(granulomatosis 
• infantiseptica)
• M. leprae(leprosy; Hansen disease)
• M. tuberculosis
• Treponema pallidum(tertiary syphilis)
• Sarcoidosis 
• Schistosomiasis

Th1cells secrete γ-interferon, activating macrophages. TNF-αfrom macrophages 

induce and maintain granuloma formation. Anti-TNF drugs can, as a side effect, cause 

sequestering granulomas to breakdown, leading to disseminated disease. Always test for 

latent TB before starting anti-TNF therapy.