Associated with hypertrophy, dilatation and systolic dysfunction of heart
Causes:
Alcohol
Doxorubicin
Peripartum
Duchenne muscular dystrophy
Viral infection have also been implicated
Alteration in genes for desmin, B myosin and troponin have also been implicated
Gross – dilatation, >900 gms, stasis causing mural thrombi endocardial fibrosis, normal valves and coronary arteries
Microscopic – myocyte hypertrophy, myofibrillar loss and interstitial fibrosis with monocyte infiltration
Clinical significance – heart failure and susceptibility to lethal ventricular arrythmia
Treatment: number one indication for heart transplant
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjYPv5nOSZwcDMgfshTAcyLOGW6tN9qOJQ-zXfWig-I1p_2AOhQ6WMHD5IGaya8Q0A6gTaeJRI8l01b0yvCbBlTGko8ReXhumBjDYJC8Qr6ibdHMM7tYIuq_FPOVgE1995rFyh1nru86v0/s320/Cardiomyopathies.png)
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiQLL43osyerkbm2WwSRtVDWqbcMlOGlsveHeIGZrZNDKdwtg78DoOzbT4417fATndfX6SJrBd3KTiqB33JvxxKJ52q8yBIPypPqTHo3H7UE9RL5egdN2ryHFemIzm5ivcruLfmHVyERss/s320/Dilated+cardiomyopathy.png)
Dilated cardiomyopathy
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhBIKHckzXMfg3KsgFsFKOxvfCXxuVr-E0IcAansJ-4XiKby3InrQIHppF0ogu3JP7wJs9QjrUKObW5c8udpGqcwxA5CaL4nF-JYMtppLKtOe_7wORwrE11EOtB6ho1xAp9C8_zgo8v5yc/s320/Cardiomyopathy+%25E2%2580%2593+trichrome+stain+1.png)
Cardiomyopathy – loss of myofibrils
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