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Mechanical Ventilation in ARDS - USMLE

FiO2 and PEEP both use to improve oxygenation, in ARDS, in the beginning you give high FiO2 and PEEP to improve oxygenation, once PaO2 is normal

then you first decrease FiO2 and keep it below 60 and then decrease PEEP, to wean off your target FiO2 should be less then 40

Note :

  • Increasing FiO2 depresses respiratory drive
  • PEEP keeps alveoli open at the end of expiration and it improves ventilation and gas exchange
  • FiO2 should not be more than 60 for more than 48hrs it will cause oxygen toxicity, which will further destroy the lung.


  1. It is therefore important to have a home ventilation system that allows your home to bring in fresh air and expel contaminated air. If your home is insulated, commercial ventilation will ensure that pollutants in the air that are harmful to the health and that can damage the house are not trapped inside.

  2. There are many different types of ventilation systems including natural, mechanical and smoke ones ventilation systems Each of these fulfils a different purpose and is necessary or desirable for particular types of structures.