Chronic Hepatitis

Inflammation is initially limited to portal tracts and consists of lymphocytes, macrophages, occasional plasma cells; forming Lymphoid aggregates

periportal necrosis and bridging necrosis

Portal and periportal fibrosis

Formation of bridging fibrous septa

HBV: "ground-glass" hepatocytes, "sanded" nuclei

HCV: bile duct epithelial cell proliferation, lymphoid aggregate formation

Cirrhosis: The end-stage outcome

Fibrosis with regenerative nodules with proliferating hepatocytes.