What is Gout ?

A disorder of uric acid crystals deposition in joints

Primary Gout (90% of cases)

Enzyme defects unknown (85%–90% of primary gout): Overproduction of uric acid

Underexcretion of uric acid with normal production

Secondary Gout (10% of cases)

Associated with increased nucleic acid turnover—e.g., leukemias and tumor lysis syndrome

Chronic renal disease: Reduced excretion of uric acid

Inborn errors of metabolism—e.g., complete HGPRT

Hypoxanthine-guanine phosphoribosyltransferase deficiency (Lesch-Nyhan syndrome).