nodular goiter may predispose
RAS mutations in follicular adenomas and carcinomas suggests that they may be related tumors
Hürthle cell variants of follicular carcinomas may be seen
extensive histologic sampling of the tumor-capsule-thyroid interface is needed, to exclude capsular and/or vascular invasion
follicular lesions in which the nuclear features are typical of papillary carcinomas should be regarded as papillary cancers.
metastasize through the bloodstream to the lungs, bone, and liver
Well-differentiated metastases may take up radioactive iodine, so can be used for therapy
Because better differentiated lesions may be stimulated by TSH, exogenous thyroxine is given to supress the TSH in the body .