Inflammatory Bowel disease.

result from an abnormal local immune response against the normal flora of the gut, and probably against some self antigens, in genetically susceptible individuals
Crohn disease may affect from esophagus to anus but most often involves the ileum; about half of cases exhibit noncaseating granulomatous
Ulcerative colitis is a nongranulomatous disease limited to the colon
First-degree relatives are 3 to 20 times more likely
Pathogenesis include imbalance between 2 factors

(1) factors that activate the host immune system, such as luminal microbes, dietary antigens, and endogenous inflammatory stimuli; and
(2) host defenses that down-regulate inflammation and maintain the integrity of the mucosa


Genetic Predisposition:

Ulcerative colitis has been associated with HLA-DRB1, whereas
HLA-DR7 and DQ4 alleles are associated with approximately 30% of Crohn disease

Immunologic Factors

predominant class of T-cell response.The inflammatory cytokine TNF may play an important role and TNF antagonist are used in the treatment
neutrophils initially and mononuclear cells later in the course
perinuclear antineutrophil cytoplasmic antibodies, which are present in about 75% of persons with ulcerative colitis

End results:

(1) impaired integrity of the mucosal epithelial barrier, and
(2) loss of surface epithelial cell absorptive function

2 comments:

  1. mbbs in Philippines
    Every year, almost 8000 foreign students take admission in Philippines Medical universities and out of which around 50% are Indian students. The standard of education in Philippines universities is well known around the world. Thousands of doctors from these medical universities are sent to various countries like USA and UK every year. There are around 2299 higher educational institutions and 40 medical colleges. The main benefits of pursuing MD degree from

    Top Medical Colleges in Philippines :

    EMILIO AGUINALDO COLLEGE OF MEDICINE
    UNIVERSITY OF PERPETUAL HELP SYSTEM DALTA
    LYCEUM NORTHWESTERN UNIVERSITY
    DAVAO MEDICAL SCHOOL FOUNDATION
    SOUTHWESTERN UNIVERSITY

    Top Searched Topics on MBBS in Philippines


    study mbbs in philippines
    philippines medical colleges list
    best medical colleges in philippines for indian students
    philippines medical colleges
    best medical colleges in philippines
    mci approved medical colleges in philippines

    for more information contact us : +91 90329 55688

    ReplyDelete
  2. UV GULLAS COLLEGE OF MEDICINE is one of Top Medical College in Philippines in Cebu city. International students have the oppertunity to study medicine in phillipines at affordable cost and world class University. The college has successful alumni who have achieved well in the fields of law, business, politics, academe, medicine, sports and other endeavors. At University of the Visayas, we prepare students for a global competition.

    Direct MBBS Admissions Open: 2020-21
    Mobile No: +91 90329 55688
    Apply Now: https://www.careerplus.org.in/philippines-medical-college/uv-gullas-college-of-medicine

    ReplyDelete

Popular Posts