Neoplastic cells closely resemble NORMAL GERMINAL CENTER B CELLS
Two principal cell types are observed in varying proportions
SMALL CLEAVED CELLS - centrocytes (Majority)
Larger cells called CENTROBLASTS
Nodular growth pattern is observed in involved lymph nodes
Involvement of extranodal sites is RARE
Transformation to diffuse large B cell lymphoma occurs in 30-50% cases
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcXvcyeEf9hDX2hW1Q2AhvQH4RY_e9xJ6q3ohmS3339nEqFXaup8PM8AN7Qan26YHU7Oql-KVhgMp1QxBnnla7834Cqr1bNRcopusGH45KLeHPt703SjdU2JvClDo0X3RnALmqvcEd7CTL/s320/Follicular+Lymphoma.png)
The follicles are numerous and irregularly sized.
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