Rapidly Progressive Glomerulonephritis (RPGN).

Type I RPGN (Anti-GBM Antibody)

Idiopathic
Goodpasture syndrome

Type II RPGN (Immune Complex)

Idiopathic
Postinfectious
Systemic lupus erythematosus
Henoch-Schönlein purpura (IgA)

Type III RPGN (Pauci-Immune)

ANCA associated
Idiopathic
Wegener granulomatosis

Microscopic polyarteritis nodosa/microscopic polyangiitis
proliferation of the parietal epithelial cells of Bowman's capsule in response to injury and in part by infiltration of monocytes and macrophages forms crescents
crescents eventually obliterate Bowman's space and compress the glomeruli


Crescentic glomerulonephritis (PAS stain). Note the collapsed glomerular tufts and the crescent-shaped mass of proliferating cells and leukocytes internal to Bowman capsule.

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